Why Your Anti-Wrinkle Results May Fade Faster Than Before (And what you can do about it—backed by real science)
- IOANA MARCU
- Dec 1
- 3 min read
Introduction
You’ve had anti-wrinkle treatments before, and they worked like a dream. But recently... something’s changed. Your results don’t last as long. Your skin feels heavier. You’re questioning if it’s even working at all.
At Pure Aesthetics Clinic, we’ve seen it all—from new clients concerned their previous treatments have lost their sparkle, to loyal patients noticing subtle changes after years of consistent injectables.
This blog explains why that might be happening, what the science says, and what you can do to bring back smoother, longer-lasting results.
📌 Table of Contents
💉 How Anti-Wrinkle Injections Work
Anti-wrinkle injections work by temporarily relaxing specific facial muscles, softening lines and preventing deeper wrinkles from forming. Most patients see results within 3–7 days, with effects peaking around 2 weeks and lasting between 3–4 months.
However, this timeline can vary based on:
Product type
Dosage and dilution
Your body’s metabolism
Muscle strength and facial activity
Repeated exposure over time
❗ 5 Reasons Your Results May Fade Faster
1. Muscle Memory + Resistance
Over time, your facial muscles may "learn" to work around the treatment. Rarely, your body may also develop neutralising antibodies against botulinum toxin type A, as discussed in this review by Fabbrocini et al. (2018): Clinical, Cosmetic and Investigational Dermatology – PubMed
2. High Metabolism
Are you highly active? If you work out daily or have a fast metabolism, your body may break down the product more quickly—meaning shorter-lasting results.
3. Underdosing or Product Switching
If the dosage isn’t tailored to your current needs (e.g., stronger muscles, deeper lines), results may fade quicker. Some brands also vary in unit strength, so switching between them may affect longevity.
5. Stress & Lifestyle
Stress, poor sleep, alcohol, smoking, and sun exposure can reduce the skin's ability to heal and regenerate. This can make your anti-wrinkle results appear less effective or shorter-lasting.
🔧 What You Can Do About It
Reassess Your Treatment Plan: You may benefit from a different dosage, injection pattern, or even switching to a different neuromodulator brand.
Space Treatments Wisely: Over-treating can reduce efficacy. We recommend 12–16 week intervals between sessions.
Support with Skin Boosters or Microneedling: Adding skin health support improves overall glow and enhances results.
Review Supplements and Skincare: Some supplements may improve skin resilience (collagen, zinc, vitamin C), while harsh skincare can counteract injectables.
🕰️ When It’s Time to Reassess Your Plan
If you've noticed:
Results lasting less than 8–10 weeks
A “heavy” or unnatural feeling after treatment
Uneven movement or residual lines
…it’s time for a fresh consultation.
At Pure Aesthetics Clinic, we offer free, no-pressure consultations to assess where you are now and help you find your best path forward.
🌿 Conclusion
Anti-wrinkle treatments are still one of the most effective, low-downtime ways to soften signs of aging. But if you’ve been doing them for years, and you’re not getting the same results anymore—it’s not just in your head.
Your body changes. Your skin evolves. Your treatment plan should too.
Let’s take a fresh look—together.
❓ FAQ
Q: Can I become immune to anti-wrinkle injections?
A: In very rare cases, yes. Your body may produce antibodies that reduce effectiveness. This can be addressed by changing product or approach.
Q: How do I know if I need more units or a different plan?
A: A personalised review with a Nurse Prescriber can help identify if dose adjustment or technique changes are needed.
Q: Is there a test for resistance?
A: There is no routine test for it, but treatment history and clinical review offer strong clues.
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